Gwaje-gwajen Laboratory

Kiyasta lokacin karantawa: 7 minti daya

Ana iya buƙatar gwaje-gwajen gwaje-gwaje daban-daban (NT-PROBNP, T4, cTn-I, gwajin parasite na jini, sigogin biochemical, cikakken ƙididdigar jini, da sauransu) don fahimtar canje-canje a cikin jikin da cutar ta haifar da sakamakon gwajin jini na zuciya ko don samun ƙimar da za ta iya samar da ma'anar magani.

Kada a manta cewa wasu yanayi na zuciya na iya canzawa a sakamakon wasu cututtuka na rayuwa, gazawar gabobi, cututtuka na endocrinal, rashin daidaituwa na ruwa-electrolyte, cututtuka ko cututtuka na parasitic a cikin jiki.

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Alamar Halittar Zuciya a cikin Jini a cikin MMVD

Tare da ƙaruwa mai tsanani na Mitral Valve Disease (MMVD), N-terminal pro-B nau'in natriuretic peptide (NT-proBNP) ve cardiac troponin I (cTnI) An kuma bayar da rahoton ƙara yawan abubuwan da ke nuna alamun cututtukan zuciya kamar su.

Cardiac troponin I (cTnI), alama ce mara ƙayyadaddun ƙayyadaddun lalacewa na myocardialSabili da haka, karuwa a cikin wannan alamar a cikin jini zai iya faruwa ba kawai saboda cututtukan zuciya ba amma kuma saboda nau'o'in cututtukan cututtukan zuciya daban-daban.

NT-proBNP alhali, alama ce da aka saki a cikin wurare dabam dabam don mayar da martani ga mikewar myocardial don haka alama ce ta cardiomegaly (kara girman zuciya)Ma'aunin NT-proBNP, tasiri a bambance tsakanin MMVD mai laushi (matakin B1) da matsakaici-zuwa-tsanani MMVD (matakin B2-D) nunawa.

A cikin lokuta na gaggawa, NT-proBNP, Zai iya zama da amfani don bambance ƙarar ƙimar numfashi da ƙoƙari saboda gazawar zuciya ta gefen hagu (CHF) daga haɓakar cututtukan da ke haifar da na numfashi na farko.Duk da haka, a cikin karnuka Kasancewa tare da cututtukan numfashi na farko tare da MMVD yana yiwuwa. kuma a cikin wannan yanayin ana iya iyakance ƙarin ƙimar bincike na peptides na natriuretic.

Sauran illolin wannan hanyar sun haɗa da: rashin gwaje-gwajen kulawa ve Akwai babban bambanci a cikin NT-proBNP taro tsakanin jinsi. is located.

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Alamar Halittar Zuciya a cikin Rashin Ciwon Zuciya (CHF)

Zagayewar kwayoyin halitta na zuciya, musamman N-terminal pro B-nau'in natriuretic peptide (NT-proBNP) auna ma'auni, lura da binciken asibiti don sanin ko asalin zuciya ne zai iya taimakawa.

An gudanar da bincike da yawa a cikin karnuka da kuliyoyi, Marasa lafiya tare da alamun cututtukan zuciya na zuciya (CHF), irin su dyspnea (ƙanƙarar numfashi), sun fi iya samun asalin zuciya lokacin da matakan NT-proBNP ke yawo. ya bayyana.

Bugu da kari, Ma'auni na NT-proBNP a cikin ruwa mai ruwa a cikin kuliyoyi tare da zubar da jini (rarar ruwa a cikin rami na kirji), ruwa don bambance ko ciwon zuciya ne ko kuma wanda ba na zuciya ba An same shi da amfani. Lowarancin NT-proBNP a cikin plasma ko ruwan pleuralyana sa ganewar ciwon zuciya ya ragu.

Hakanan, ma'aunin zazzagewar cardiac troponin I (cTnI)., musamman ma a cikin cats, Yana taimakawa wajen bambance gazawar zuciya yana haifar da dyspnea daga sauran cututtukan numfashiWannan yana da mahimmanci don saurin ganewar asali da kuma zaɓin magani daidai.

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Alamar cututtukan zuciya a cikin ARVC

Rage hawan jini a cikin karnukan Boxer tare da ARVC (Arrhythmogenic Dama Ventricular Cardiomyopathy) cTnI (cardiac troponin I) maida hankali na iya karuwa da Yana iya daidaitawa da mitar arrhythmias na ventricular (VA)Koyaya, banbance tsakanin karnuka da ARVC da lafiyayyen Boxers ta yin amfani da wannan alamar ba koyaushe ake yankewa ba, saboda za'a iya samun babban karo tsakanin ƙungiyoyin biyu.

Babban hankali cTnI gwaje-gwaje suna da yuwuwar haɓaka daidaiton bincike kuma ana buƙatar ƙarin bincike akan wannan batu.

Akan wannan, Yada matakan BNP a cikin karnukan Boxer tare da ARVC baya karuwa sosai don haka yana da iyakataccen matsayi a cikin ganewar asaliWannan yana iya zama saboda, yayin da BNP yawanci yana hade da haɓakar zuciya (cardiomegaly) da kuma rashin aikin ventricular na hagu, hanyoyin da ke cikin ARVC sun bambanta.

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Dilated Cardiomyopathy (DCM) da Ciwon Halittu na Cardiac

Rarraba masu biomarkers na zuciya a cikin bincike na dilated cardiomyopathy (DCM) N-terminal pro-B nau'in natriuretic peptide (NT-proBNP) ve cardiac troponin I (cTnI) kayan aiki ne masu amfani. Duk da haka, waɗannan alamomin Ba za a iya maye gurbin echocardiography ko ECG baDuk da yake waɗannan alamomin halittu ba su keɓance ga DCM ba, su ne danniya, iri da lalacewar myocardial alamun nuni ne.

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Ma'anar NT-proBNP da cTnI Biomarkers

• NT-proBNP: A cikin tsokar zuciya iri (fitarwa ga danniya) da kuma ƙara yawan matsa lamba na ƙarshen-diastolic Sabili da haka, matakan NT-proBNP masu girma suna nuni da haɓakar zuciya (cardiomegaly) da gazawar zuciya.

• cTnI: Yana da alamar lalacewar tsokar zuciya (lalacewar myocardial)Mutuwa ko lalacewa ga sel myocardial yana haifar da sakin wannan furotin zuwa wurare dabam dabam.

Haɓaka alamomin biyu, Yana iya nuna kasancewar ko ci gaban DCM, amma waɗannan alamomin ba su keɓance ga DCM ba. Ana buƙatar Echocardiography da ECG don tantance ainihin DCM.

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Matsayin NT-proBNP a cikin Ganowar DCM

• Hankali = 70-80%

• Musamman = 90%

NT-proBNP alama ce mai mahimmanci don gano DCM a farkon (preclinical) mataki. Musamman, zai iya gano binciken echocardiographic mafi kyau fiye da nau'in arrhythmic.

Saboda an saki NT-proBNP don amsawa don shimfiɗawa a cikin ganuwar tsokar zuciya, babban adadin zazzagewar wannan alamar yana da amfani a farkon ganewar asali na DCM. Duk da haka, NT-proBNP na iya nuna canje-canje na yau da kullun da na mako-mako. ve dabi'u na al'ada na iya zama mafi girma a wasu jinsi kada a manta da shi. Misali:

• Labrador Mai Ritaya ve Newfoundland NT-proBNP ƙididdige ƙididdiga na nau'in kare irin su sun fi sauran nau'in.

Don haka, ana ba da shawarar yin amfani da takamaiman jeri na tunani.

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Matsayin cTnI a cikin Bincike na DCM

• Hankali = 81%

• Musamman = 73%

cTnI (cardiac troponin I), myocardial cell lalacewa Yana daya daga cikin mafi kyawun alamomi. Lokacin da tsokar zuciya ta lalace, ana sakin cTnI daga sel kuma a sake shi cikin jini.

Ƙimar yankewa = 0,113 ng/ml an ƙaddara kamar .

Matsakaicin cTnI sama da wannan ƙimar na iya zama mai nuna kasancewar DCM. Duk da haka, cTnI saboda ƙananan ƙayyadaddun sa (ƙara ba kawai a cikin DCM ba har ma a cikin wasu lalacewar tsokar zuciya) kuma ba a ba da shawarar azaman kayan aikin ganowa kaɗai don DCM ba.

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Haɗin Amfani da NT-proBNP da cTnI

Haɗin yin amfani da NT-proBNP da cTnI na iya ƙara daidaiton bincike.

• Yayin da hankali na NT-proBNP kadai shine 70-80%,

• cTnI yana da hankali na 81%,

• Yin waɗannan gwaje-gwaje guda biyu tare, Yana ba da daidaito mafi girma a cikin bincikar DCM.

NT-proBNP yana kimanta nau'in tsoka na zuciya, yayin da cTnI ke kimanta lalacewar myocardial. Saboda haka, lokacin da aka haɗa bayanai daga alamomin biyu, duka biyu damuwa na inji har da lalacewar salula kimantawa yana yiwuwa.

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NT-proBNP don Bambance Tsakanin DCM da CHF

Sakamakon farashin hannun jari na DCM gazawar zuciya (CHF) iya ci gaba.

Tun da NT-proBNP yana da alaƙa da haɓakar zuciya (cardiomegaly) da haɓakar matsa lamba na diastolic, Amfani don bambanta tsakanin kasancewar CHF da cututtukan numfashi na farko.

• Gwajin jiki ve thoracic x-ray A cikin yanayin da ba za mu iya tantance ko akwai CHF ko a'a ba, NT-proBNP na iya zama jagora mai mahimmanci.

• Ƙwararren NT-proBNP yana nuna cewa CHF na iya kasancewa.

Duk da haka, darajar wannan gwajin. a lokuta inda ba za a iya yin echocardiography ba mafi ma'ana. Idan akwai echocardiography, ana amfani dashi don ganewar asali kai tsaye.

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Ƙayyadaddun NT-proBNP da cTnI a cikin Bincike na DCM

1. Bambancin Tsakanin Kabilanci:

Ma'auni na al'ada don NT-proBNP na iya bambanta tsakanin nau'ikan karnuka. Misali, Labrador Mai Ritaya ve Newfoundland Matsakaicin NT-proBNP na yau da kullun a cikin wasu nau'ikan ya fi na sauran nau'ikan. Don haka, ya kamata a yi amfani da kewayon tunani daban don kowane nau'in.

2. Canje-canje na yau da kullun da na mako-mako:

Ƙididdigar NT-proBNP na iya canzawa akan lokaci, daga rana zuwa rana ko ma daga mako zuwa mako. Wadannan sauye-sauye na iya haifar da rashin fahimta. Sabili da haka, ana bada shawarar ma'auni masu yawa don ganewar asali.

3. Wajibi na Echocardiography:

NT-proBNP da cTnI na iya nuna kasancewar DCM, amma Ana buƙatar echocardiography don tabbataccen ganewar asaliWadannan alamomin halittu suna taimakawa wajen gano cutar amma ba su tabbatar da kasancewar DCM kai tsaye ba.

4. Tasirin Ƙarin Cututtuka:

cTnI, kowane nau'in lalacewar myocardial na iya karuwa. A wasu kalmomi, lalacewar ƙwayar zuciya banda DCM (misali, myocarditis) na iya ƙara matakan cTnI. Saboda haka, don ganewar asali na DCM. cTnI kadai bai kamata a dogara dashi ba.

• NT-proBNP da cTnI ba sa maye gurbin echocardiography da ECG a cikin ganewar asali na DCM, amma suna ba da ƙarin bayani.

• NT-proBNP, yana ƙaruwa a mayar da martani ga bangon bangon zuciya da farkon ganowa na DCM amfani don.

• cTnIyana nuni da lalacewar ƙwayar zuciya kuma yana iya nuna kasancewar lalacewar ƙwayar zuciya a lokacin DCM.

• Don ƙara azanci a cikin bincikar DCM Ya kamata a yi amfani da duka masu alamar halitta tare.

• A lokuta da ba za a iya yin echocardiography ba, NT-proBNP yana da amfani don bambanta tsakanin CHF da cututtuka na numfashi.

Yin amfani da waɗannan alamomin halittu suna ba da damar gano farkon ganewar asali na DCM, farkon fara jiyya, da kuma lura da tasirin jiyya. Daidaitaccen ganewar asali da sa baki da wuri na iya inganta rayuwar majiyyaci da tsawaita tsawon rai. 

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Wasu Labarun Kuna iya Sha'awarsu

• Ciwon Zuciya a Karnuka
• Rashin Ciwon Zuciya a Cats
• Hawan jini na tsari
• Zagayen Zuciya
• Fitar zuciya

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"Ka'ida ta farko ita ce kada ku yaudari kanku - mutum mafi sauki don wawa shine kanku."

Richard Feynmann

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